sonic hedgehog signalling pathway Search Results


anti shh  (Boster Bio)
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Boster Bio anti shh
Anti Shh, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human shh  (Cell Signaling Technology Inc)
92
Cell Signaling Technology Inc human shh
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Human Shh, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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signaling protein sonic hedgehog (shh)  (Tanabe)
90
Tanabe signaling protein sonic hedgehog (shh)
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Signaling Protein Sonic Hedgehog (Shh), supplied by Tanabe, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog signaling  (Ligand Pharmaceuticals)
90
Ligand Pharmaceuticals sonic hedgehog signaling
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Signaling, supplied by Ligand Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog pathway  (Musashi Engineering Inc)
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Musashi Engineering Inc sonic hedgehog pathway
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Pathway, supplied by Musashi Engineering Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecule activator of the sonic hedgehog homolog pathway  (Johns Hopkins HealthCare)
90
Johns Hopkins HealthCare small molecule activator of the sonic hedgehog homolog pathway
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
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abnormal sonic hedgehog signalling  (Ayrton Drugs)
90
Ayrton Drugs abnormal sonic hedgehog signalling
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Abnormal Sonic Hedgehog Signalling, supplied by Ayrton Drugs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog signaling pathway  (Biolog Inc)
90
Biolog Inc sonic hedgehog signaling pathway
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Signaling Pathway, supplied by Biolog Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog signaling-shh neutralizing antibody  (StemRD Inc)
90
StemRD Inc sonic hedgehog signaling-shh neutralizing antibody
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Signaling Shh Neutralizing Antibody, supplied by StemRD Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog signaling pathway  (Proteostasis Therapeutics)
90
Proteostasis Therapeutics sonic hedgehog signaling pathway
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Signaling Pathway, supplied by Proteostasis Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog-glioma associated oncogene homolog 1 signaling  (Musashi Engineering Inc)
90
Musashi Engineering Inc sonic hedgehog-glioma associated oncogene homolog 1 signaling
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog Glioma Associated Oncogene Homolog 1 Signaling, supplied by Musashi Engineering Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sonic hedgehog (shh) pathway  (Glaxo Smith)
90
Glaxo Smith sonic hedgehog (shh) pathway
a, Schematic of the various <t>SHH</t> proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of <t>the</t> <t>N-terminal</t> palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.
Sonic Hedgehog (Shh) Pathway, supplied by Glaxo Smith, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


a, Schematic of the various SHH proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of the N-terminal palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.

Journal: Nature chemical biology

Article Title: The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

doi: 10.1038/s41589-019-0370-y

Figure Lengend Snippet: a, Schematic of the various SHH proteins used in signalling assays. b, Two different amounts of each SHH variant from (h) were analyzed by immunoblotting. Full gels can be found on Supplementary Figure 7. c and d, Fold-increase in Gli1 mRNA (relative to the no SHH added condition) was used as a metric for signalling strength after treatment of NIH/3T3 cells with various concentrations of the indicated ligands. e, HH signalling strength at increasing concentrations of the N-terminal palmitoylated peptide (Palm-ShhN15) in the absence or presence (100 μM) of a cholesteroylated C-terminal peptide (ShhN7-chol). In c-e, the mean is depicted and error bars reflect standard deviation (n=4). Each experiment in c-e was repeated at least 3 times.

Article Snippet: A rabbit monoclonal antibody (clone C9C5) against the N-terminal signaling domain of human SHH was obtained from Cell Signaling Technologies (cat#2207).

Techniques: Variant Assay, Western Blot, Standard Deviation